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C-3113 - Benign and malignant chest nodes staging in by diffusion weighed MRI: an alternative to mediastinoscopy?

P. Akl1, C. MESMANN2, F. Tronc2, S. A. Si-mohamed2, P. Douek2, L. Boussel2; 1 LYON/FR 2 Lyon/FR Type: Scientific Exhibit
Area of Interests: Mediastinum, Lung, Lymph nodes
Imaging Techniques: PET-CT, MR-Diffusion/Perfusion
Procedure: Endoscopy
Special Focus: Neoplasia
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Aims and objectives: • Evaluate the accuracy of DWIBS   • at 3T   • in diagnosing malignant and benign lymph nodes of the chest   • as compared to pathology results   • following mediastinoscopy  

Methods and materials: Study subjects •64 consecutive patients presenting with previously diagnosed enlarged mediastinal lymph nodes   •and scheduled for a mediastinoscopy in our hospital   •(age 58+/-14, range 27-80 years; sex ratio 39 males/14 females)   •between June 2011 and December 2013, prior to an[...]

Results: •6 patients excluded   •Poor image quality   •   •Mean ADC values: Higher in   •Begnin nodes (1740±401×10-3 mm2/s)   •Than malignant nodes (1266±403×10-3 mm2/s, p=0.0001)   •   •Mean RRC-b800 values: Lower in   •Begnin nodes (2.64±1.07)   •Than malignant [...]

Conclusion: •DWIBS may represent a useful adjunctive imaging modality, particularly for diagnosis of benign mediastinal lymph node, and thus may reduce the frequency of futile mediastinoscopy, which remains an invasive procedure.   •However, larger prospective studies are warranted to assess changes in pat[...]

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References: •1]  T.C. McLoud, P.M. Bourgouin, R.W. Greenberg, J.P. Kosiuk, P.A. Templeton, J.A. Shepard, E.H. Moore, J.C. Wain, D.J. Mathisen, H.C. Grillo, Bronchogenic carcinoma: analysis of staging in the mediastinum with CT by correlative lymph node mapping and sampling., Radiology. 182 (1992) 319–323. [...]

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