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C-3026 - PET/CT investigation of bowel 18F-FDG uptake in non-diabetic individuals: incidence and potential clinical significance in oncology

R. N. Mitchell-Hay1, M. Macnab1, A. Yucel-Finn2, R. Staff1, F. Mckiddie1, S. Olson1, E. Ramage1, J. Straiton1, G. Baio1; 1 Aberdeen/UK 2 Inverness/UK Type: Scientific Exhibit
Area of Interests: Small bowel, Colon, Oncology
Imaging Techniques: PET-CT, PET
Procedures: Physiological studies, Comparative studies, Statistics
Special Focuses: Biological effects, Cancer, Artifacts
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Aims and objectives: 18F-FDG is the most commonly used ligand in PET imaging. Higher 18F-FDG uptake is exhibited in the body at sites of increased metabolic activity and therefore is routinely used to diagnose and stage patients with a range of cancer types, as well as non-cancerous conditions such as vasculitis and inf[...]

Methods and materials: Imaging 1049 individual patients who had undergone full body PET/CT scans between May 2014 and September 2015 at ARI were included in the study. PET/CT images were acquired with an integrated PET-CT scanner. The patients were most commonly scanned with their hands above their heads from skull[...]

Results: The cohort used consisted of those patients with complete information available: 428 females and 531 males, mean age 62.7y (range 1.2-89.7years), mean height 169cm (range 86-196cm), mean weight 76.1kg (range 9.8-184kg) and mean BMI 26.6 kg/m2 (range 13.3-50.5kg/m2). BMI categorisation showed th[...]

Conclusion: Among non-diabetic patients, 18F-FDG bowel uptake positively and independently correlates with suspected lung and oesophageal cancers. The high prevalence of bowel uptake among lung cancer patients has been seen previously (Vella-Boucaud, 2015), although not directly compared with the prevalence amo[...]

Personal information: Dr Rosalind N Mitchell-Hay Department of Radiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, AB25 2ZD. UK r.mitchell-hay@nhs.net   Margo-Rose Macnab, M.Sc. Nuclear Medicine, Department of Radiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, AB25 2ZD. UK margo-rose.m[...]

References: Bybel. et. al (2011). Increased F18-FDG intestinal uptake in diabetic patients on metformin: a matched case control analysis. Clinical Nuclear Medicine , 36 (6), 452-456. de Groot, M. et. al (2005). Influence of blood glucose level, age and fasting period on non-pathological FDG uptake in hea[...]

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