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C-2615 - Up to 52 administrations of macrocyclic ionic MR contrast agent are not associated with intracranial gadolinium deposition: multifactorial analysis in 385 patients

H. Kim, J. Park, J. Lee, S. Jung, C. Choi, S. Kim; Seoul/KR Type: Scientific Exhibit
Area of Interests: Neuroradiology brain, CNS
Imaging Technique: MR
Procedure: Comparative studies
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Aims and objectives: To determine whether multiple repeated administrations of macrocyclic ionic MR contrast agent (gadoterate) are associated with increasing T1 signal intensity in the dentate nuclei and globus pallidus and identify the predisposing factors for T1 signal increase in various clinical situations.

Methods and materials: Patient Inclusion (Figure 1) Patients were evaluated with routine laboratory tests before the MR examinations. Patient data were obtained from electronic medical record, including the sex and age of the patients, indication for MR imaging, renal and hepatic function, and a history of chemotherapy or[...]

Results: The mean DN/P SI ratio difference was not different from zero (P = .08), even in patients with ≥20 administrations (n = 24). The mean DN/P SI ratio difference was not associated with any predisposing factors. However, the mean GP/Th SI ratio difference decreased (P < .0001), which was associated [...]

Conclusion: Multiple repeated administrations of gadoterate in various clinical situations are not associated with intracranial T1 signal increase in the dentate nuclei and globus pallidus.

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References: 1. Kanda T, Ishii K, Kawaguchi H, Kitajima K, Takenaka D. High signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images: relationship with increasing cumulative dose of a gadolinium-based contrast material. Radiology 2014;270(3):834-841. 2. Ramalho J, Castillo [...]

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