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C-2677 - The role of MRI in the evaluation of Graves orbitopathy: a clinical-radiological correlation study

A. Di Napoli, L. Pasquini, A. Romano, A. Boellis, M. Rossi Espagnet, A. Bozzao; Rome/IT Type: Scientific Exhibit
Area of Interests: Thyroid / Parathyroids, Eyes
Imaging Technique: MR
Procedure: Computer Applications-Detection, diagnosis
Special Focus: Inflammation
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Aims and objectives: Graves’ ophthalmopathy (GO) is a chronic inflammatory autoimmune disease of periorbital tissue, conjunctiva and retrobulbar structures, especially involving extraocular muscles (EOM). The clinical course is characterized by two phases:  the “active phase”, which hystologically shows mononuclear[...]

Methods and materials: MR examinations of 58 patients with affected by GO were retrospectively included. In each patient "signal intensity ratio" values (SIR) in the most affected extrinsic orbital muscle, chosen on the basis of a greater signal intensity in both T2 and post-contrast T1-weighted sequences, ocular proptosi[...]

Results: The statistical analysis showed a significant correlation between T2-SIR value and CAS (p=0.023) at diagnosis and during follow-up. CE-SIR correlated only with TRAb title (p=0.008). Finally the global MR index (T2 SIR + proptosis + optical nerve impingement) correlated with both CAS (p=0,036) and an[...]

Conclusion: In our study, MR orbits evaluation demonstrates a good correlation with clinical informations in patients affected by GO at diagnosis and during follow-up. Our results confirm the utility of a global MR index to support clinicians in the management of GO, improving a multidisciplinary approach to th[...]

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References: 1.      Dickinson AJ, Perros P. Thyroid-associated orbitopathy: who and how to treat. Endocrinol Metab Clin N Am. 2009; 38 (2): 373-388. 2.      Prummel MF, Gerding MN, Zonneveld FW, et al. The usefulness of quantitative orbital magnetic resonance imagin[...]

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