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C-3007 - CT texture analysis of clear cell renal carcinoma (ccRCC) in a radiogenomics prospective - a pilot study

S. Badia, D. Bellini, M. Rengo, D. Caruso, S. Picchia, A. Laghi; Latina/IT Type: Scientific Exhibit
Area of Interest: Kidney
Imaging Technique: CT-Quantitative
Procedure: Radiobiology
Special Focus: Molecular, genomics and proteomics
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Aims and objectives: Clear cell Renal carcinoma (ccRCC) is a common group of chemotherapy-resistant tumour and represents 2%–3% of adult malignancies, with the clear cell histotype (ccRCC) accounting for 80%–90% of all RCCs. (1) It is the third most common urological cancer after prostate and bladder cancer, but it has [...]

Methods and materials: 67 patients who underwent contrast enhanced CT of abdomen and pelvis for suspected ccRCC between April 1, 2014 and June 1, 2016, were considered eligible for inclusion into the study. Subjects were considered ineligible for this study if (i) the CT examination resulted in no kidneys malignancies; (i[...]

Results: For association of texture parameters with mi-RNA values linear multiple regression model methods was used. Analysis was performed for each of the six parameters at each filter level and for each contrast phase (i.e. contralateral healthy kidney, arterial phase, portal phase and urographic phase).&n[...]

Conclusion: In summary, our results reveal that, for Patients affected by ccRCCs, CTTA features are associated with tumor histologic findings, in particular texture parameter as Kurtosis is correlated with up-regulation of oncogenic miRNAs like miRNA-21-5p and miRNA-221-3p. Texture analysis from MDCT so can be[...]

Personal information: Stefano Badia, M.D. "Sapienza" - University of Rome Faculty of Medicine and Dentistry Department of Radiological Sciences, Oncology and Pathology Diagnostic Imaging Unit - I.C.O.T. Hospital, Latina - ITALY stefano.badia@gmail.com   Davide Bellini, M.D. "Sapienza" - University of Rome Facu[...]

References: Siegel R.; Naishadham D.; Jemal A. Cancer statistics, 2013. CA: Cancer J. Clin. 2013, 63, 11–30. Jonasch E.; Futreal P.A.; Davis I.J.; et al. State of the science: An update on renal cell carcinoma. Mol. Cancer Res.: MCR 2012, 10, 859–880. Schaefer A; Carsten S.; Busch J. et al. Diagnostic, prognos[...]

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