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B-0006 - Hypovascular hypointense nodules on hepatobiliary phase without T2 hyperintensity on gadoxetic acid-enhanced MRI: long-term outcomes and risk factors of hypervascularisation

H. Yang, J. Song, E. Choi, E. Park; Jeonju-si/KR Type: Scientific Paper
Area of Interests: Liver, Abdomen
Imaging Techniques: CT, MR
Procedure: Screening
Special Focuses: Cancer, Cirrhosis
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Purpose: To evaluate the ‘long-term’ outcome and risk factors associated with hypervascularization in hypovascular hypointense nodules on hepatobiliary phase (HBP) without T2 hyperintensity on gadoxetic acid-enhanced magnetic resonance (MR) images in patients with chronic liver disease.

Methods and materials: The institutional review board-approved retrospective analysis included 97 chronic liver disease patients with 222 hypovascular hypointense nodules on HBP without T2 hyperintensity on gadoxetic acid-enhanced MRI. The following MR features were analyzed: nodule size, presence of fat, degree of hypoin[...]

Results: The mean follow-up interval was 997 days (range, 137–1804 days). 41 nodules (18.5 %) became hypervascular hepatocellular carcinoma (HCC). Both univariate and multivariate Cox analysis identified that previous history of HCC, follow-up nodule size, degree of hyperintensity at T1WI and DWI were signif[...]

Conclusion: The previous history of HCC, follow-up nodule size, degree of hyperintensity at T1WI and DWI were associated with progression to hypervascular HCC.

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References: 1.        Torre, L.A., et al., Global Cancer Incidence and Mortality Rates and Trends--An Update. Cancer Epidemiol Biomarkers Prev, 2016. 25(1): p. 16-27.   2.        Choi, B.I., K. Takayasu, and M.C. Han, Small hepatocellula[...]

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