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C-2264 - Neurosarcoidosis: A pictorial review.

T. Buende Tchokouako1, H. Nejadhamzeeigilani1, J. L. Nix1, I. Craven1, D. J. Warren1, J. Macmullen-Price2, S. Currie1; 1 Leeds/UK 2 LEEDS/UK Type: Educational Exhibit
Area of Interest: CNS
Imaging Technique: MR
Procedure: Decision analysis
Special Focus: Tissue characterisation
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Learning objectives: To review the most common Magnetic Resonance Imaging (MRI) features of neurosarcoidosis.

Background: Sarcoidosis is an inflammatory multisystem disorder of unknown aetiology characterised by the presence of non-caseating granulomas in tissues. Practically, no organ is immune to sarcoidosis but it most commonly affects the lungs and lymph nodes. When sarcoidosis affects the brain it is termed neuros[...]

Findings and procedure details:  Leptomeningeal involvement  Leptomeningeal involvement occurs with predilection for the basilar cisterns in about 40% of patients with neurosarcoidosis. Gadolinium enhancement can be diffuse or nodular on post-contrast T1 weighted MRI (Fig. 1).           H[...]

Conclusion: Neurosarcoidosis has a wide spectrum of imaging features that mimic both benign and malignant conditions. MRI is highly sensitive for detecting neurosarcoidosis, but is not specific. This pictorial review has highlighted salient features which should raise the suspicion of a potential diagnosis of n[...]

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References: Osborn AG. Osborn’s Brain: Imaging, Pathology, and Anatomy. Wolters Kluwer | Lippincott Williams & Wilkins; 2012    Ginat DT, Dhillon G, Almast J. Magnetic Resonance Imaging of Neurosarcoidosis. Journal of Clinical Imaging Science. 2011;1:15.   Hoyle JC, Jablonski C, Newton HB[...]

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