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B-0624 - Brain gliomas recurrence imaging after chemoradiation therapy

A. Smirnova1, O. V. Lukina1, N. Plakhotina1, I. Lobanov2, A. Kuzmin1, A. Tkachev3; 1 Saint-Petersburg/RU 2 Nizhny Novgorod/RU 3 Volgograd/RU Type: Scientific Paper
Area of Interests: Oncology, CNS
Imaging Techniques: Gamma knife, PET-CT, MR
Procedures: Stereotactic radiotherapy, Efficacy studies
Special Focus: Cancer
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Purpose: Radiotherapy at the present stage provides a wide range of possibilities of glial brain tumors treatment. Subsequent interpretation of dynamic changes which are difficult. The present study assessed structural MRI of all possible options postradiation changes of gliomas in combination with other dia[...]

Methods and materials: For the period from 2014 to 2016, the study involved 1o1 patients aged 24-69 years (mean age 55 years) who received different kinds of radiation therapy on the glial tumors. All patients were divided into two groups. Group A consisted of patients with gliomas I-II grade (58), group B consisted of pa[...]

Results: In the control MRI researches in different periods revealed the following changes at the site of radiation exposure. 1. Resize: a) reducing the size of tumor in 23% in group A, in 9% in group B; b) stabilization of the dimensions of tumor in 46% in group A, in 18% in group B; c) increase (hemorrhage[...]

Conclusion: The data of CT and MRI with contrast enhancement in the case of radiation necrosis is not specific. However, objective evaluation process is very important because the assignment of cytostatic therapy may increase the severity of the patient's condition and lead to further necrosis progress. Cu[...]

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References: 1. Macdonald D.R., Cascino T.L., Schold S.C. Jr, Cairncross J.G. Response criteria for phase II studies of supratentorial malignant glioma. J Clin Oncol. 1990 Jul;8(7):1277-80.  2. Wen P.Y., Macdonald D.R., Reardon D.A., Cloughesy T.F., Sorensen A.G., Galanis E., Degroot J., Wick W., Gilbert M.[...]

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