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C-0737 - Experimental works on thermal conduction during cryoablation

S. Nakatsuka, H. Yashiro, M. Inoue, M. Tamura, S. Oguro, H. Torikai, J. Tsukada, M. Jinzaki; Tokyo/JP Type: Scientific Exhibit
Area of Interests: Interventional non-vascular, Animal (veterinary) studies, Oncology
Imaging Technique: Experimental
Procedure: Ablation procedures
Special Focus: Cancer
Please note: This poster is part of the session VoE 16 - Japanese on Friday, March 3, 10:00 - 11:00 Add poster to my schedule In your schedule (remove)

Aims and objectives: There are some important unanswered questions concerned with cryoablation. One is the lethal temperature of a specific tumor, and another is the required nonlethal margin which is related to ice-ball size. In this study, the time-dependent changes in isotherms during cryoablation in various porcin[...]

Methods and materials: Cryoablation and Time-temperature Curve Measurements of Porcine Organs The present study was granted approval by the Keio University Animal Experiment Committee. The experiments were performed using male domestic pigs (3 months old, approximate weight 40 kg). After right thoracotomy and/or laparotom[...]

Results: Time-temperature curves for all measuring points were successfully measured for every 5 seconds (Fig. 3A). The data were converted into isothermal curves for each 5 second period by means of PC calculation (Fig. 3B, Fig. 4). Isothermal radii were calculated from the areas inside the isothermal curve[...]

Conclusion: Our experimental study contains several concepts; differences in ablation zone in porcine non-aerated and aerated organs, differences of nonlethal margins according to temperature and organs, and a new suggestion about the ratios between radii for ice-balls and those for a specific temperature. A pr[...]

Personal information: Seishi Nakatsuka. Department of Diagnostic Radiology, Faculty of Medicine, Keio University, Tokyo, Japan.

References: 1. Gage AA, Baust. Mechanisms of tissue injury in cryosurgery. J. Cryobiology 1998; 37: 171-86. 2. Georgiades C, Rodriguez R, Azene E, Weiss C, Chaux A, Gonzalez-Roibon N, Netto G. Determination of the Nonlethal Margin Inside the Visible ‘‘Ice-Ball’’ During Percutaneous Cryoablation of Renal Tissue.[...]

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