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C-1740 - CT and MRI pattern of Progressive Multifocal Leukoencephalopathy.

V. Mellou1, C. Chrona2, A. Kalpaksi2, D. Kavatha2, M. Tsilika2, K. Spyrou1; 1 ATHENS/GR 2 Athens/GR Type: Educational Exhibit
Area of Interests: Neuroradiology brain, CNS
Imaging Techniques: MR, CT
Procedure: Diagnostic procedure
Special Focuses: Education and training, Infection, Monoclonal antibodies
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Learning objectives: To demonstrate the imaging manifestations of PML on computed tomography (CT) and magnetic resonance imaging (MRI) and outline the role of imaging in diagnosis ,follow-up and prognostication.

Background: Progressive multifocal leukoencephalopathy (PML) is a rare but often fatal disease of the central nervous system (CNS) with destructive infection of oligodendrocytes by JC virus[1]. The disease has an insidious onset with HIV infection as underlying illness in 85% of cases [2,4] but it is also obse[...]

Findings and procedure details: Our institute provides a dedicated service for this small group of patients .Last year two patients were confirmed with PML in our hospital. Radiological manifestations included  symmetric -asymmetric  zones of low attenuation involving the peri-ventricular, subcortical white matter, grey [...]

Conclusion: The natural course of PML is fatal within months .Imaging plays a critical role in the initial detection of PML. Recognition of imaging findings reflecting active demyelination may help the clinician to assist with prompt patient management. Despite the fact  that demonstration of JC virus usi[...]

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References: 1. Berger JR, Concha M (1995) Progressive multifocal leukoencephalopathy: the evolution of a disease once considered rare. Neurovirol (1) 5–18   2. Focosi D, Marco T, Kast RE, Maggi F, Ceccherini-Nelli L, Petrini M. Progressive multifocal leukoencephalopathy: what's new?. Neuroscien[...]

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