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B-1031 - Human long bone development in intrauterine growth restriction: in vivo analysis of the distal femoral epimetaphysis on prenatal MR imaging

U. Nemec, S. F. Nemec, P. C. Brugger, D. Prayer; Vienna/AT Type: Scientific Paper
Area of Interests: Obstetrics (Pregnancy / birth / postnatal period), Bones, Foetal imaging
Imaging Technique: MR
Procedure: Intrauterine diagnosis
Special Focus: Fetus
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Purpose: To investigate human long bone development in fetuses with intrauterine growth restriction (IUGR) by analyzing distal femoral epimetaphyseal structures and bone morphometrics on prenatal MR imaging.

Methods and materials: This retrospective study included 14 fetuses (mean gestational age, 26 weeks 2 days; range, 21 weeks 3 days to 33 weeks) with intrauterine growth restriction caused by placental insufficiency, without other brain or body abnormalities. Furthermore, we included a total of 192 age-matched fetuses[...]

Results: The morphometric measurements of the IUGR fetuses did not exceed the minimum normative measurements at any gestational age (diaphyseal length: p < 0.0001 - 0.0053; epiphyseal length: p < 0.0001 - 0.0022; epiphyseal width: p < 0.0001 - 0.0032). Overall, the same grading for cartilaginous epi[...]

Conclusion: On prenatal MR imaging, fetuses with placental-based IUGR exhibit long bone shortening, whereas their qualitative bone characteristics appear within normal limits. Consequently, the presence of qualitative bone abnormalities should include the differential diagnosis of various fetal skeletal disorde[...]

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References: 1. Sharma, D., S. Shastri, and P. Sharma, Intrauterine Growth Restriction: Antenatal and Postnatal Aspects. Clin Med Insights Pediatr, 2016. 10: p. 67 - 83. 2. Nemec, U., et al., Human long bone development in vivo: analysis of the distal femoral epimetaphysis on MR images of fetuses. Radiology, 2[...]

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