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C-2772 - A comparison of conventional and synthetic MRI in assessment multiple sclerosis

W. Krauss, M. Gunnarsson, M. Lundin, P. Thunberg; Örebro/SE Type: Scientific Exhibit
Area of Interests: Computer applications, MR physics, Neuroradiology brain
Imaging Technique: MR
Procedures: Physics, Diagnostic procedure, Decision analysis
Special Focus: Image verification
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Aims and objectives: To compare the assessment of patients with multiple sclerosis using synthetic and conventional MRI.

Methods and materials:   Synthetic and conventional axial images were obtained for 39 patients with diagnosed MS using a 1.5 Tesla system. Quantitative MRI (1,2) was first used for measuring proton density and relaxation times and then, based on these parameters, synthetic T1W, T2W and FLAIR images were calculated. S[...]

Results:     Figure 1-3 show examples of conventional and synthetic T1W, T2W and FLAIR images. There was no significant difference in lesion detection using synthetic and conventional MRI in any anatomical region (periventricular, juxtacortical, infratentorial or cerebrum) or for any of the three i[...]

Conclusion: Synthetic MR images show promising results for being an alternative to conventional MR images in MS diagnostics. The radiological review of the conventional MR images resulted in higher inter-and intra-rater agreements compared to synthetic MR which speaks for the use of conventional MRI for the tim[...]

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References: 1. Warntjes JB et al. Rapid Magnetic Resonance Quantification on the brain: Optimization for Clinical Usage. Magn Reson Med. 2008 Aug;60(2):320-9.   2. Krauss W et al. Accuracy and reproducibility of a quantitative magnetic resonance imaging method for concurrent measurements of tissue relaxati[...]

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