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C-2179 - Predicting Effect Of Radiosurgery On Optic Tracts By Diffusion Tensor Imaging: Initial Report

M. Yazol1, H. Özer1, B. Barutcu2, A. Onay3, G. KURT1, H. emmez1, A. ONER1; 1 Ankara/TR 2 ANKARA/TR 3 Istanbul/TR Type: Scientific Exhibit
Area of Interests: Neuroradiology brain, Computer applications
Imaging Technique: MR-Diffusion/Perfusion
Procedures: Radiation effects, Stereotactic radiotherapy, Radiation safety
Special Focuses: Radiotherapy techniques, Endocrine disorders
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Aims and objectives: Stereotactic radiosurgery (SRS) is being increasingly used to treat patients with sellar and parasellar tumors, including pituitary adenomas, meningiomas and craniopharyngiomas (1). The safety and efficacy of SRC has been demonstrated in the clinical practice.  It has prolonged latency period[...]

Methods and materials: Twenty five patients with sellar and parasellar region tumors referred  for gamma knife radiosurgery were included in this prospective study (age range 30-74, mean 54, 17 women).   All of patients underwent single-session Gamma Knife radiosurgery . The prescription dose ranged from 9 to 2[...]

Results: All DTI parameters of optic nerves were significantly different between pre and post- radiosurgery group at early stage (p<0,05). Mean FA values were significantly lower, ADC, AD, RD values were significantly higher than pre- radiosurgery values. FA values were significantly reduced, ADC signific[...]

Conclusion: We suggest that the decrease in FA values by 3-months is associated with axonal demyelination and axonal disintergration and increase in ADC values at 3-months probably reflect breakdown of blood brain barrier (BBB). AD values significantly increased compared to pre- radiosurgery, which suggested t[...]

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References: 1. Stafford SL, Pollock BE, Leavitt JA, Foote RL, Brown PD, Link MJ, et al. A study on the radiation tolerance of the optic nerves and chiasm after stereotactic radiosurgery. International Journal of Radiation Oncology* Biology* Physics. 2003;55(5):1177-81. 2. Kondziolka D, Levy EI, Niranjan A, Flic[...]

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