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C-2528 - A case report of PET/MRI with rapidly progressive encephalopathy, probable Creutzfeldt-Jakob disease.

G. A. PE√ĎA1, M. Guirao2, V. X. Rada2; 1 MENDOZA/AR 2 Mendoza/AR Type: Educational Exhibit
Area of Interests: Nuclear medicine, Neuroradiology brain, Hybrid Imaging
Imaging Techniques: MR-Diffusion/Perfusion, PET-MR
Procedures: Molecular imaging, Diagnostic procedure
Special Focuses: Infection, Inflammation
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Learning objectives: PET/MRI is a new modality for molecular imaging with a promise to be the method of choice for brain imaging of neurodegenerative diseases, tumors of the central nervous system and diseases of difficult diagnosis as the one exposed in this poster. The ensambling of the brand new PET techology with ul[...]

Background: Rapidly progressive dementias (RPDs) comprise a group of diseases characterized by the development of cognitive and behavioral disorders that evolve over weeks to a few months [1]. Those entities mislead the clinician who does not expect such a rapid progression of the illness. Thus, many patients w[...]

Findings and procedure details: Scan Protocol: A PET/MRI with time of fly (3D TOF) PET and 3 Tesla MR acquisition was made, after 45 minutes of a165 MBq dose of 18F-Fluordeoxyglucose (FDG). MRI secquences included: 3-point Dixon sequence for PET attenuation correction (Water, Fat, In Phase and Out Phase), Sagital T1 FLAI[...]

Conclusion: The combined metabolic and morphologic information provided by PET/MRI devices can improve and give a more definite diagnosis of rapidly progressive encephalopaties as the case of CJD. Diffusion secquences must be included on these entities, being more sensitive than other T2 based secquences for de[...]

Personal information: PET CT and PET MRI Unit, FUESMEN, Mendoza, Argentina

References: [1] Geschwind MD, Haman A, Miller BL. Rapidly progressive dementia. Neurol Clin 2007;25:783-807. [2] Roberson ED, Hesse JH, Rose KD, et al. Frontotemporal dementia progresses to death faster than Alzheimer disease. Neurology 2005;65:719-725.   [3] Graus F, Keime-Guibert F, Rene R, et al. Anti[...]

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