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C-0187 - Osteoblastic lesion screening with an advanced post-processing package enabling in-plane rib reading in CT-images

H. Seuss, P. Dankerl, A. Cavallaro, M. Uder, M. Hammon; Erlangen/DE Type: Scientific Exhibit
Area of Interest: Oncology
Imaging Technique: CT
Procedure: Segmentation
Special Focus: Metastases
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Aims and objectives: The most common type of malignant bone tumors found are metastases. These originate from various cancer types with high incidence and prevalence, such as prostate cancer, breast cancer and colon cancer [1]. Up to 70% of prostate cancer patients develop bone metastases, which are typically osteoblast[...]

Methods and materials: Patient Population In this retrospective study 60 patients (male; mean age, 72 years; range, 48 - 89 years) with histologically confirmed prostate cancer who underwent thoraco-abdomino-pelvic CT imaging were included. In the analyzed period, four patients were scanned twice and one patient three tim[...]

Results: Standard of Reference (Multiplanar Read) A total of 473 sclerotic lesions were found in 183 ribs in 21 patients. In an additional 2 patients, diffuse, unmeasureable osteoblastic lesions were present in all ribs. Therefore, 23 of 60 patients presented with at least one sclerotic rib lesion (median of[...]

Conclusion: In a cohort consisting of 60 patients with prostate cancer, a total of 473 sclerotic rib lesions were found in 23 patients. The software correctly displayed 94% of the ribs in plane. In 88% of patients all ribs were displayed correctly in plane. As demonstrated, all patients with suspected sclerotic[...]

Personal information: Hannes Seuss, Department of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Maximiliansplatz 1, 91054 Erlangen, Germany   Peter Dankerl, Department of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-N[...]

References: 1. Roodman GD. Mechanisms of bone metastasis. The New England journal of medicine 2004; 350: 1655-1664 2. Heindel W, Gubitz R, Vieth V et al. The diagnostic imaging of bone metastases. Deutsches Arzteblatt international 2014; 111: 741-747 3. Siegel R, Ma J, Zou Z et al. Cancer statistics, 2014. CA: [...]

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