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C-0602 - CARDIAC AMYLOIDOSIS: literature review and MRI characteristics

m. macchia1, D. De Falco Alfano1, F. coppola2, R. Righi3, M. Zerbini3, M. Giganti3, G. Benea4; 1 Cona (FE)/IT 2 Lecce/IT 3 Ferrara/IT 4 Lagosanto (FE)/IT Type: Educational Exhibit
Area of Interests: Cardiovascular system, Cardiac
Imaging Techniques: Echocardiography, MR
Procedures: Diagnostic procedure, Technical aspects
Special Focuses: Pathology, Tissue characterisation
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Learning objectives: -Describe pathophysiology of systemic amyloidosis and its main types with cardiac involvement. -Describe main Magnetic Resonance Imaging (MRI) signs and characteristics of cardiac amyloidosis.     -Describe main exam techniques in MRI for the study of cardiac amyloidosis and propose new [...]

Background: Amyloidosis comprises a heterogeneous group of diseases characterized by a progressive accumulation of normally soluble plasma proteins in an abnormal, insoluble fiber, named amyloid, which create amyloid deposits in the extracellular space causing the alteration of the normal tissue architecture an[...]

Findings and procedure details: Amyloid protein can infiltrate any cardiovascular structures such as conduction system, atrial and ventricular myocardium, valve tissue, coronary arteries and large blood vessels. Generally, myocardial infiltration progressively thickens and hardens ventricular walls and interatrial septum, however [...]

Conclusion: To early identify alterations related to amyloid infiltration in the cardiac tissue, recent studies show that the multiparametric MRI evaluation (LGE+T1 mapping) appears to be more sensitive than the evaluation through ECG+ECHOCARDIOGRAPHY. Cardiac Magnetic Resonance (CMR) is a valid non-invasive to[...]

Personal information: Matteo Macchia, University of Ferrara, via aldo moro 8, Cona, Ferrara (FE).   matmacchia@hotmail.com

References: - Fontana M., Pica S., Reant P., Moon J.C. et Al., “Prognostic Value of Late Gadolinium Enhancement cardiovascolar manetic resonance in cardiac amyloidosis” ; Circulation 2015; 132: 1570-1579   - Ruberg F. L., Nezafat R.; “Cardiovascular Magnetic Resonance visualization of cardiac Amyloid infi[...]

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