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C-0156 - Whole-Lesion histogram analysis metrics of the apparent diffusion coefficient (ADC) as a marker of breast lesions characterization at 1.5T

A. Christou1, A. Ghiatas2, D. Priovolos2, K. S. Veliou3, H. Bougias3; 1 Doncaster/UK 2 ATHENS GREECE/GR 3 Ioannina/GR Type: Scientific Exhibit
Area of Interest: Breast
Imaging Technique: MR-Diffusion/Perfusion
Procedure: Diagnostic procedure
Special Focus: Cancer
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Aims and objectives: Introduction The role of diffusion weighted imaging (DWI) in differentiating and characterizing breast tumours has been recently investigated in many reports. It has been already shown to increase the breast MRI diagnostic efficacy and specificity to 89% from 75%. DWI can also be evaluated in a qu[...]

Methods and materials: Subjects We prospectively enrolled 49 women with mean age 54 years old (37 to 71 years old) with 53 breast lesions. DWI was applied as a part of our standard breast MRΙ protocol together with DCE-MRΙ in all cases. The main referral indications were: preoperative local staging of the tumor and clar[...]

Results: Malignancy was diagnosed in 34 cases through the course of histological verification. Biopsy was performed after the MRI in all cases included in this study. Surgery was performed according to the pathological results. The remaining 19 lesions were categorized as benign; their majority (17 cases) un[...]

Conclusion: The whole-lesion histogram analysis of ADC map is a useful MRI index and could play an important role in the differentiation between benign and malignant breast tumors. Mean, mode and 10th/50th/90th percentile ADCs and skewness showed statistical significance between benign and malignant breast tumo[...]

Personal information: Bougias Haralambos bbougias@yahoo.gr   Alexandra Christou alexandrachristou@gmail.com Veliou Konstantia ntinavel@gmail.com Priovolos dimitrios priovolosdimitris@gmail.com Ghiatas Abraham abraham@otenet.gr

References: 1. Kul S, Cansu A, Alhan E, Dinc H, Gunes G, Reis A. Contribution of Diffusion-Weighted Imaging to Dynamic Contrast-Enhanced MRI in the Characterization of Breast Tumors AJR 2011; 196:210–217 2. Guo Y, Cai YQ, Cai ZL, et al. Differentiation of clinically benign and malignant breast lesions using dif[...]

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