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C-2915 - Visualization of the liver colorectal metastases using iodine maps based on dual-energy computed tomography (DECT): preliminary results

P. W. Ratajczak, P. Strześniewski, M. Drzewiecka, M. Juszczak, M. Słupski, Z. Serafin; Bydgoszcz/PL Type: Scientific Exhibit
Area of Interests: Colon, Liver, Abdomen
Imaging Technique: CT
Procedure: Staging
Special Focus: Metastases
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Aims and objectives: BACKGROUND: Colorectal cancer (CRC) is 2nd most common cancer, diagnosed in 1.2 million patients, responsible for 0.55 million deaths in developed countries. 25% of patients presents with metastatic disease at the time of diagnosis. 25% of patients will develop metastases after curative resection. 2[...]

Methods and materials: Twenty patients aged between 33 and 79, scheduled for surgery due to metastatic liver disease were included into the study. All patients had a previous confirmation of metastatic CRC by conventional CT. Examinations were performed at 64-row scanner using GSI mode.    Scanning parameters:&n[...]

Results: The mean iodine concentration in metastases was 800 μg/cm3 in arterial phase, 1630 μg/cm3 in portal phase, and 1320 μg/cm3 in venous phase. The concentrations in normal parenchyma were 600 μg/cm3, 2170 μg/cm3, and 1310 μg/cm3, respectively (P<0.02, ANOVA) (Fig 3).     metastases [...]

Conclusion: DECT seems to be a promising method to improve sensitivity of computed tomography in the detection of metastases to the liver. New tools introduced by spectral imaging, including iodine uptake maps, increased tissue resolution enabling better delineation hepatic lesions from surrounding, sometimes c[...]

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References: 1. Metastatic colorectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. E. Van Cutsem1, A. Cervantes2, B. Nordlinger3 & D. Arnold4, on behalf of the ESMO Guidelines Working Group Ann Oncol (2014) 25 (suppl 3): iii1-iii9   2. Systemic treatment of live[...]

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