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B-0349 - Functional connectivity analysis in differential diagnostics of chronic disorders of consciousness

E. I. Kremneva, E. Zmeykina, L. Legostaeva, A. Poidasheva, A. Chervyakov, D. Sergeev, J. Ryabinkina, N. Suponeva, M. Piradov; Moscow/RU Type: Scientific Paper
Area of Interests: CNS, Neuroradiology brain
Imaging Techniques: MR, MR-Functional imaging
Procedures: Technology assessment, Computer Applications-Detection, diagnosis
Special Focus: Trauma
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Purpose: Chronic disorders of consciousness (DOC) are characterized by varying levels of disconnection between various cerebral networks (Laureys 2000, 2002). One of the most important networks is the default mode network (DMN), that may have crucial role in DOC development and in the emergence of consciousn[...]

Methods and materials: Fourteen patients with DOC (CRS-rVS=4, CRS-rMCS-=5, CRS-rMCS+=5, mean age 26+-2,0) with permanent terms of brain damage (trauma and anoxic) were admitted in Research Center of Neurology (Moscow). Also we included 4 healthy volunteers (mean age 24+-1,7). We examined all of them by means of resting st[...]

Results: We obtained functional connectomes for 3 groups of DOC patients – vegetative state, minimally consciousness state «minus», minimally consciousness state «plus» and healthy group (Fig.1) In a group of vegetative state we did not get any reliable significant correlation. After constructing the connect[...]

Conclusion: The connectoms' number of connections in ROI multiplies with the level of consciousness increase. In particular, MPFC may be of most important value for further investigations because of its relations with other DMN zones. The correlation coefficient increases of this exact region of interest as opp[...]

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References: 1.Laureys et al. (2000) Restoration of thalamocortical connectivity after recovery from persistent vegetative state. Lancet 355(9217):1790-1. 2.Laureys et al.(2002) Cortical processing of noxious somatosensory stimuli in the persistent vegetative state. Neuroimage17(2):732-41. 3.Vanhaudenhuyse et al[...]

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