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C-1964 - Multiparametric hippocampal analysis using DTI Surface Based Analysis and MR Spectroscopy to assist in Temporal Lobe Epilepsy research

D. Tsivaka1, E. Kapsalaki2, K. Fountas3, K. Theodorou3, I. Fezoulidis4, I. Tsougos3; 1 Larisa/GR 2 LARISSA/GR 3 Larissa/GR 4 Nikaia - Larissa/GR Type: Scientific Exhibit
Area of Interest: Neuroradiology brain
Imaging Techniques: MR-Spectroscopy, MR-Diffusion/Perfusion, MR
Procedure: Computer Applications-3D
Special Focus: Seizure disorders
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Aims and objectives: Epilepsy is the fourth most common serious neurological disorder and TLE (Temporal Lobe Epilepsy), the most frequent form of refractory focal epilepsy. MRI Epilepsy protocols have been already established in many centers in order to facilitate the detection and localization of the seizure focus. The[...]

Methods and materials: 3D MRI, DTI and MR Spectroscopy data were acquired from 20 normal controls, age–matched with two patients with right TLE (19-25 years old) on a GE Signa HDxt 3.0T scanner. DTI images were utilized by GE Functool (GE Milwaukee, USA) and ExploreDTI (developed by Alexander Leemans) in order to calculat[...]

Results: Hippocampal Volumetry Hippocampal volume measurements were derived from 20 healthy adults and two age-matched patients with right TLE via FreeSurfer and were normalized with TIV, which was calculated separately via SPM12.   Controls: The average TIV (mean and SD x10-3)) for the normal group w[...]

Conclusion: Surface-Based Analysis software such as FreeSurfer and Statistical Parametric Mapping software such as SPM12 are powerful tools for the analysis and visualization of structural neuroimaging data. Advanced MRI techniques may be able to detect hippocampal sclerosis and atrophy, which can be verified[...]

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References: Schwartzkroin Philip A. Ph. D. Role of the hippocampus in epilepsy.,HIPPOCAMPUS , Vol.4, No.3, Pages 239-242, June 1994. Ju Ho Kim1, Dae Seob Choi2,7, Seong-hu Kim3, Hwa Seon Shin2, Hyemin Seo2, Ho Cheol Choi2, Seungnam Son4, Woo Suk Tae5, Sam Soo Kim., Evaluation of Hippocampal Volume Based on Vari[...]

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