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C-1794 - Diagnostic accuracy of bone scintigraphy, positron emission tomography/computed tomography (PET/CT) and whole body magnetic resonance imaging (MRI) in the detection of bone metastasis among patients with prostate cancer using histopathologic report and / or clinical follow-up as the reference standard: A systematic review

E. Acayan1, C. AQUINO2, I. BANDONG2; 1 Quezon City/PH 2 QUEZON CITY/PH Type: Scientific Exhibit
Area of Interests: Oncology, Hybrid Imaging, Genital / Reproductive system male
Imaging Techniques: PET-CT, MR, Nuclear medicine conventional
Procedures: Screening, Molecular imaging
Special Focuses: Cancer, Metastases
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Aims and objectives: GENERAL OBJECTIVE To compare the accuracy of bone scintigraphy, PET/CT, and MRI in the diagnosis of bone metastasis. SPECIFIC OBJECTIVE To determine the sensitivity, specificy, positive likelihood ratio (PLR), negative likelihood ration (NLR), accuracy, positive predictive value (PPV), and negativ[...]

Methods and materials: SEARCH METHODS We searched the following electronic databases: PUBMED, MEDLINE, EMBASE, The Cochrane Library SELECTION CRITERIA All prospective or retrospective cross-sectional studies (the year of publication from 2010 to 2016) were included. Included patients were diagnosed with prostate cancer [...]

Results: RESULTS OF THE SEARCH A total of 27 articles were identified. Eight full-text articles were assessed for eligibilty, of which three articles were qualified to be included in the final analysis. METHODOLOGICAL QUALITY OF INCLUDED STUDIES Three studies were included in the review (Figures 1 and 2). [...]

Conclusion: This study showed that bone scan can be used to help distinguish patients with diffuse osseous metastases from patients with no skeletal metastasis. However, for patients with prostate cancer, FDG PET/CT and whole body MRI have a higher diagnostic value for detecting bone metastasis. The authors r[...]

Personal information: E. Acayan. Department of Nuclear Medicine, St. Luke's Medical Center, Quezon City, Philippines. C. Aquino. Institute of Radiology, St. Luke's Medical Center, Quezon City, Philippines. I. Bandong. Department of Nuclear Medicine and Institute of Radiology, St. Luke's Medical Center, Quezon City, Phili[...]

References: Damle NA, Bal C, Bandopadhyaya GP, Kumar L, Kumar P, Malhotra A, Lata S.. The role of 18F-fluoride PET-CT in the detection of bone metastases inpatients with breast, lung and prostate carcinoma: a comparison with FDG PET/CT and 99mTc-MDP bone scan. Jpn J Radiol. 2013 Apr;31(4):262-269. Minamimoto R,[...]

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