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B-1197 - Native T1 mapping comparison of mean and median assessment reveal reduced T1 in normal anterior and anterolateral segments compared to the rest of the myocardium

P. Triadyaksa, T. D'Antonoli, N. Prakken, M. Oudkerk, P. E. Sijens; Groningen/NL Type: Scientific Paper
Area of Interest: Cardiac
Imaging Technique: MR
Procedures: Statistics, Segmentation
Special Focus: Tissue characterisation
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Purpose: T1 mapping has been recognized for its ability to characterized myocardial tissue to improve the detection of cardiac disease [1]. Native T1 has shown its role in determining myocardial fibrosis without injecting contrast media. To differentiate the fibrosis tissue with the normal one, the evaluatio[...]

Methods and materials: Retrospective analysis of 1.5T MOLLI sequence MRI data (Figure 1) acquired with motion correction was applied to map native T1 by using Custom-written software (developed in MATLAB version 7.14, The MathWorks, Natick, MA, USA) in the myocardium of 63 patients that turned out to have a normal heart e[...]

Results: Median myocardial native T1 values were significantly lower than the means (P<0.001) as seen in Table 1 and Figure 2. The median assessment produced significantly less segmental T1 variation among patients with higher fitting precision (P<0.001) in the global and segmental analysis. Evaluated [...]

Conclusion: Median assessment reduces measurement variability in global and segmental native T1 mapping of the myocardium. Variation of normal heart T1 values was apparent on segmental analysis, a novel finding with implications for pathological evaluation.  

Personal information: The authors declare that they have no conflicts of interest. P. Triadyaksa received funding support from DGHE scholarship of the Ministry of Research, Technology and Higher Education of Indonesia.

References: [1] Moon JC, Messroghli DR, Kellman P, et. al. Myocardial T1 mapping and extracellular volume quantification: a Society for Cardiovascular MagneticResonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement. J Cardiovasc Magn Reson. 2013 Oct 14;15:92.   [2][...]

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