E³ 126a - Oncologic imaging in the age of precision medicine
1. To understand the meaning of precision medicine.
2. To document the role of radiologists in precision medicine.
3. To understand how precision imaging will have an influence on the practice of radiology.
According to the National Institutes of Health (NIH), precision medicine (PM) is "an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person". Its development is stimulated by the progresses in data intensive basic science, and is characterized by a high level of complexity. The key pillars of PM are: to develop a new taxonomy of diseases based on biological mechanisms, to develop correlations of phenotyping with genotyping, to increase the statistical power of research in developing networking and integrated databases. The main national plans or programmes, which are currently being developed, will be briefly presented in order to highlight the cost and the complexity of this concept. Imaging has certainly an important role in this framework: the development of reliable quantitative biomarkers and the delivery of structured data are crucial. Correlations between phenotype and genotype through radiogenomic approaches appear promising. Concrete examples will be presented to illustrate the potential of imaging in this context mostly in oncology (tumour heterogeneity mapping). The importance of companion diagnostics will be discussed as well as liquid biopsy, which potentially is a strong competitor as well.
1. To review how radiologists can contribute to radiomics investigation.
2. To explain state-of-the-art of radiomics, from science to practise.
3. To learn about the idea of radiomics.
Radiogenomics is the correlation between image-derived features and gene expression. Recent scientific progress has enabled the treatment of cancer based on targeting of specific mutations. Imaging, in contrast to biopsies, allows the assessment of the entire tumour volume. The presentation will explain the state of the art in the field and discuss the contributions that radiology can make.
1. To explain what is the present and the future of imaging-guided interventions.
2. To learn about current concepts for precise imaging guidance during IR procedures.
3. To understand the practical implementation of such tools.
Modern oncologic care is centred on the molecular characteristics of an individual’s cancer in what is termed precision medicine. The image-guided needle biopsy has been the key tool used to access the cancer for molecular analysis. Radiologists as central players in needle biopsy, thus, play a critical role in precision medicine. Recent data show that many specimens are insufficient to provide enough material for molecular analysis. This lecture will focus on optimising biopsies through improved techniques, tools and work flow. In addition, we will see how radiologists can use molecular status to help distinguish between responders and non-responders of locoregional therapies.