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C-2699 - Simulation of tracer dose reduction in 18F-FDG-PET/MRT: effect on oncologic reading, image quality and artifacts

F. F. Seith1, H. Schmidt1, J. Kunz1, T. Küstner2, S. Gatidis1, K. Nikolaou1, C. La Fougère1, N. Schwenzer1; 1 Tübingen/DE 2 Stuttgart/DE Type: Scientific Exhibit
Area of Interests: Nuclear medicine, Oncology, Hybrid Imaging
Imaging Techniques: Nuclear medicine conventional, PET-MR
Procedure: Molecular imaging
Special Focuses: Dosimetric comparison, Artifacts, Molecular, genomics and proteomics
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Aims and objectives:   With the increasing use of positron emission tomography (PET) in oncologic imaging and therefore in repetitive follow-up examinations, radiation exposure increases for patients as well as for technologists and physicians [1]. Today’s guidelines for tracer doses in PET are mostly based on phan[...]

Methods and materials: We retrospectively simulated the stepwise reduction of 18F-FDG doses of 19 patients (14 female, 50.9 ± 11.7 y/o, Body-Mass-Index (BMI) 22.8 ± 3.2) from 3 to 0.5 MBq/kgBW in intervals of 0.25. All patients were examined in a whole-body PET/MRI scanner from cranial base to thighs. Objective imaging pa[...]

Results: An example of all reconstructed simulated doses of a patient is given in Fig. 2. With decreasing doses, regions in the mid abdomen showed a stronger decrease of SUVmean and NECR than regions in the upper abdomen (Fig. 1 and 3). CV in all organs showed a non-linear increase, pronounced below 1.5 MBq/[...]

Conclusion: A reduction of 18F-FDG-doses down to 2 MBq/kgBW might be possible in whole-body PET/MRI examinations of oncologic patients. The impact of reducing doses on image quality and SUV measurements is highly dependent on body regions, mostly affecting the middle abdomen. Photopenic artifacts in the middle [...]

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References: [1] S. Leide-Svegborn, Radiation exposure of patients and personnel from a PET/CT procedure with 18F-FDG, Radiation protection dosimetry 139(1-3) (2010) 208-13. [2] M.E. Daube-Witherspoon, J.S. Karp, M.E. Casey, F.P. DiFilippo, H. Hines, G. Muehllehner, V. Simcic, C.W. Stearns, L.E. Adam, S. Kohlm[...]

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