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C-3145 - congenital heart disease and the placenta: results from a fetal MRI programme

L. Mlczoch, G. M. Gruber, S. Dekan, I. Michel-Behnke, C. WORDA, U. SALZER-MUHAR, D. Prayer, G. Kasprian; Vienna/AT Type: Scientific Exhibit
Area of Interests: Obstetrics (Pregnancy / birth / postnatal period), Pediatric, Cardiac
Imaging Techniques: Echocardiography, MR
Procedures: Outcomes analysis, Computer Applications-General
Special Focuses: Outcomes, Congenital, Fetus
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Aims and objectives: Introduction Little is known about the role of the placenta in the presence of congenital heart disease (CHD). This fetal magnetic resonance imaging (MRI) study aimed to assess the frequency of placental abnormalities in fetuses with CHD.

Methods and materials: Material and Methods 1.5 tesla MRI data of 189 fetuses (aged 18-35 gestational weeks - GW) with CHD were retrospectively reviewed. The placenta was evaluated on T1, T2, echoplanar (b=0) and diffusion weighted (b=700) sequences. MRI–based Grannum stages served as reference for placental signal chara[...]

Results: Results Fetuses with CHD show significantly higher Grannum stages than expected on T1 weighted images in 25% (43/170),(p=.003) T2-w images in 29% (53/182) (p<.001) and diffusion weighted images in in 5% (8/156). (<0.05).  A thickened edematous placenta  was noted in 7%. Placental he[...]

Conclusion: Conclusion Fetal MRI detects placental abnormalities in up to 1/3 of CHD fetuses. Abnormalites were most significant on T2 weighted images .  No specific correlation to a CHD type lesion was found.  Placental pathology may aggravate the neurodevelopmental consequences of CHD and may be co[...]

Personal information: Dr Lila Mlczoch Pediatric Heart Center Vienna Medical University of Vienna Austria

References: ADDIN EN.REFLIST 1.         Mlczoch E, Brugger P, Ulm B, Novak A, Frantal S, Prayer D, et al. Structural congenital brain disease in congenital heart disease: results from a fetal MRI program. European journal of paediatric neurology : EJPN : official journal [...]

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