Local Time : 05:09 CET

C-2681 - A temporal subtraction with optimized three dimensional nonrigid registration improves the detection of spinal metastases on CT

Y. Ichikawa1, D. Hasegawa2, R. Nakyama1, Y. Watanabe2, Y. Kurita2, M. Nagata1, S. Murashima2, H. Sakuma1; 1 Tsu/JP 2 Matsusaka/JP Type: Scientific Exhibit
Area of Interests: Bones, Computer applications, Musculoskeletal bone
Imaging Techniques: CAD, CT
Procedure: CAD
Add poster to my schedule In your schedule (remove)

Aims and objectives: Early diagnosis of bone metastases is crucial because treatment before the development of substantial morbidities such as spinal compression can improve outcomes and quality of life [1-3]. Although there are limited objective data, it has been postulated that bone metastases can be frequently missed[...]

Methods and materials: Subjects  Two serial thin-slice CT datasets from chest to pelvis in 27 cancer-bearing patients (male/female, 13/14; age, 68±12 years) were studied. Of the 27 patients, 15 patients had 39 spinal metastatic foci (mean size of the lesions, 14.0±7.5mm) that emerged on the 2nd CT. The 39 spinal met[...]

Results: The image processing of the TS technique with 3D non-rigid registration was completed in all subjects. Representative cases are shown in Fig.2 and Fig.3. The number of metastatic foci detected on the 2nd CT with the TS technique was significantly higher than that without the TS technique (26.3 ± 10.[...]

Conclusion: Temporal subtraction technique with 3D non-rigid registration, based on pixel velocities caused by edge and gradient of the objects on CT, improves the detection of spinal metastases on serial CT images.

Personal information:

References: Lipton A. Pathophysiology of bone metastases: how this knowledge may lead to therapeutic intervention. J Support Oncol 2004;2:205-213. Theriault RL, Lipton A, Hortobagyi GN, et al. Pamidronate reduces skeletal morbidity in women with advanced breast cancer and lytic bone lesions: a randomized, place[...]

This website uses cookies. Learn more