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B-0308 - Multispectral magnetic particle imaging for real-time 3D MPI-guided treatment of a vessel stenosis

J. Salamon, M. Hofmann, C. Jung, M. Kaul, R. Reimer, A. vom Scheidt, G. Adam, T. Knopp, H. Ittrich; Hamburg/DE Type: Scientific Paper
Area of Interests: Interventional vascular, Radiation physics, Abdomen
Imaging Techniques: Image manipulation / Reconstruction, Experimental, Catheter arteriography
Procedures: Angioplasty, Computer Applications-Detection, diagnosis, Technology assessment
Special Focus: Image registration
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Purpose: Magnetic particle imaging (MPI) is a fast, radiation free, sensitive, and quantifiable imaging modality using superparamagnetic iron oxide particles (SPIO) as tracer [1]. Potential MPI utilizations include cardiovascular applications such as angiographies and endovascular interventions [2]. As initi[...]

Methods and materials: A standard guide wire and balloon-catheter were labeled with a thin layer of magnetic lacquer at the tip of the wire and on both sides of the balloon ( Fig. 1 ). A vessel phantom with a stenosis was either filled with saline or super paramagnetic iron oxide particles (MM4) and equipped with bimodal [...]

Results: Real time multicolored visualization of the different tracers' distinct magnetic fingerprints at a rate of 6 frames/s ( Fig. 4 ), as well as MRI/MPI-roadmapping using bimodal fiducial markers, was feasible allowing MPI-guidance for PTA ( Fig. 5 ). The magnetic lacquer consisted of 10-20 nm thick iro[...]

Conclusion: Multicolored MPI allows for 3D real-time guidance of endovascular instruments and PTA. A combination of MPI/MRI for an anatomical road map in addition to multispectral interventions with a blood pool agent might emerge as a promising tool for radiation free interventions.

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References: [1]   Gleich B and Weizenecker J. Nature. 2005;435(7046):1214-7. doi: nature03808 [pii]/10.1038/nature03808. [2]   Borgert J et. al. J Cardiovasc Comput Tomogr. 2012;6(3):149-53. doi: 10.1016/j.jcct.2012.04.007. [3]   Haegele J et. al. Radiology. 2012;265(3):933-8. doi: 10.1[...]

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