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C-3032 - Post-procedural imaging assessment of residual Yttrium-90 activity in microsphere delivery systems using next generation digital photon counting PET/CT.

C. L. Wright1, K. Binzel1, J. Zhang1, M. Jedlicka1, R. L. Anderson1, D. Konate1, P. MANIAWSKI2, M. V. Knopp1; 1 Columbus/US 2 Cleveland/US Type: Scientific Exhibit
Area of Interests: Nuclear medicine, Radioprotection / Radiation dose, Interventional non-vascular
Imaging Technique: PET-CT
Procedure: Radioembolisation
Special Focuses: Quality assurance, Image verification
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Aims and objectives: Yttrium-90 is a high energy beta emitting radioisotope used clinically for targeted radiotherapy. In particular, it is used for the radioembolization of tumor-induced neovasculature in patients with unresectable hepatic malignancies and metastases. Because of Yttrium’s lack of discrete gamma photons[...]

Methods and materials: In this study, fifteen 90Y delivery systems were imaged after routine interventional radioembolization using a pre-commercial release dPET/CT system (Vereos, Philips). The residual 90Y doses were estimated to be <100 MBq. All images were acquired in list-mode using a single bed position for 60min[...]

Results: Following routine radioembolization, ultra-low residual 90Y activities (average +/- SD = 27.7 +/- 23.8 MBq) ranging from 4.9 – 90.7 MBq) within the delivery systems were detectable with dPET/CT ( Fig. 3 ). Residual 90Y activity was noted in the source vial and, in most cases, the catheter tubing ( F[...]

Conclusion: Digital PET enables detection and quantification of ultra-low residual 90Y activity in delivery systems within 7min acquisition times. It also appears feasible that total image acquisition times as short as 7 min are feasible for consistent visualization of 90Y activity when compared with 60 min acq[...]

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References: Theranostic Imaging of Yttrium-90; Wright CL, et al. (2015) BioMed Research International doi:10.1155/2015/481279tional doi:10.1155/2015/481279

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