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B-0926 - Predicting axillary lymph node metastasis in breast cancer with multimodality imaging

J. CHo, J. Moon, S. Koh, H. Hwang, S. Park; Anyang si/KR Type: Scientific Paper
Area of Interests: Lymph nodes, Nuclear medicine, Breast
Imaging Techniques: PET-CT, Ultrasound, MR
Procedure: Screening
Special Focuses: Cancer, Metastases
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Purpose: The purpose of this retrospective study is to compare the diagnostic performances of mammography, ultrasound (US), magnetic resonance imaging (MRI) and positron emission tomography/computed tomography (PET/CT) and their various combinations to evaluate preoperative axillary lymph node metastasis (AL[...]

Methods and materials: From January 2011 to December 2014, we included 322 patients with breast cancer completed four preoperative imaging examinations (mammography, US, MRI and PET/CT) up to 3 weeks before surgery. All patients underwent breast conserving surgery or mastectomy and either ipsilateral sentinel lymph node b[...]

Results: Out of all possible combinations, mammography and US (MG+US) showed the best diagnostic performance. Regarding each single modality, mammography showed the highest specificity, however, its sensitivity was much lower than the other types of imaging. Furthermore, US revealed the highest diagnostic pe[...]

Conclusion: Routine basic studies using MG+US are enough for patients with breast cancer prior to ALNM. The addition of other modalities (e.g., MRI or PET/CT) is not necessary to evaluate ALNM; in fact it might decrease the specificity and PPV.

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References: 1.          Singletary SE, Connolly JL. Breast cancer staging: working with the sixth edition of the AJCC Cancer Staging Manual. CA: a cancer journal for clinicians. 2006;56(1):37-47. 2.          Purushotham AD, Upp[...]

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