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C-0009 - 68Ga-DOTANOC and 68Ga-DOTATATE PET/CT Molecular imaging of Neuroendocrine tumors

P. Shriduth; Trivandrum/IN Type: Educational Exhibit
Area of Interests: Molecular imaging, Hybrid Imaging, Oncology
Imaging Technique: PET-CT
Procedure: Diagnostic procedure
Special Focuses: Cancer, Neoplasia
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Learning objectives: To prospectively demonstrate the efficacy of 68Ga-DOTANOC and  68Ga-DOTATATE PET/CT as an accurate imaging technique in the detection of Neuroendocrine tumors(NETs) for the following indications: Localize primary tumor and detect sites of metastatic disease (staging). Follow-up patients with k[...]

Background: Neuroendocrine tumors (NETs) are rare malignancies of a heterogeneous biologic nature. Their incidence has been increasing over the past decades, and improvements in diagnosis, including imaging as an essential part, are such that these tumors are increasingly diagnosed[...]

Findings and procedure details: Procedure details 68Ga is an on-site generator-produced positron emitter with a short half-life of 68 minutes. 68Ga is chelated to the peptide by means of the organic compound 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid (DOTA). The use of the&n[...]

Conclusion: 68Ga-DOTANOC and 68Ga-DOTATATE PET/CT should be considered as the first-line diagnostic imaging modality of choice for Neuroendocrine tumors. It is an accurate, highly sensitive and specific imaging technique in detection of localizing primary tumor and detect sites of metastatic disease in ini[...]

Personal information: Dr. Shriduth. P . MD (Radiology)

References: Hallet J1, Law CH, Cukier M, Saskin R, Liu N, Singh S.Exploring the rising incidence of neuroendocrine tumors: a population-based analysis of epidemiology, metastatic presentation, and outcomes.Cancer. 2015 Feb 15;121(4):589-97 Velikyan I, Sundin A, Sörensen J, et al. [...]

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