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C-1028 - Volume and Mass Doubling Times: The Early Indicators of Growth of Pulmonary Nodules Detected in LDCT Screening Population in Different Risk Status

Q. Sun, W. Tang, S. Zhao, Y. Huang, N. Wu; Beijing/CN Type: Scientific Exhibit
Area of Interest: Lymph nodes
Imaging Technique: CT
Procedure: Screening
Special Focus: Cancer
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Aims and objectives: To evaluate and compare volume doubling time (VDT) and mass doubling time (MDT) of persistent pulmonary nodules (PNs) detected with low-dose computed tomography (LDCT) in screening population in different risk status.  

Methods and materials: Screening participants underwent LDCT from March 2009 to December 2015. According to the National Comprehensive Cancer Network (NCCN) guideline for lung cancer screening,all participants were assigned to three groups (high risk, moderate risk and low risk). In this ethics-committee approved retrospe[...]

Results: For PSNs group, both VDT and MDT were significantly different from the other two groups (VDT: P=0.027 for PSNs versus NSNs and P=0.003 for PSNs versus SNs; MDT: P=0.031 for PSNs versus NSNs and P=0.001 for PSNs versus SNs). For High-risk group, both VDT (P<0.001) and MDT (P<0.001) were significantly[...]

Conclusion: VDT and MDT could predict accurately the growth trend of persistent pulmonary nodules in LDCT screening. Both the characteristic of the nodule and the risk status can affect the VDT and MDT. MDT is more sensitive than VDT especially for the part solid nodules. The high risk group shows significantly[...]

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References: 1.      Brambilla E, et al. Lung cancer. In: Stewart BW, Wild CP, eds. World cancer report 2014. International Agency for Research on Cancer. 2014:350-61.   2.      Jemal A, et al. Cancer statistics, 2010. CA Cancer J Clin, 2010, 60(5): 277-300.[...]

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