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C-3009 - Brain and spine atrophy predicts neurological deterioration in relapsing remitting multiple sclerosis

I. Krotenkova; Moscow/RU Type: Scientific Exhibit
Area of Interests: Neuroradiology spine, Neuroradiology brain
Imaging Technique: MR
Procedure: Sclerosis
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Aims and objectives: To investigate predictive value of central nervous system atrophy for disability progression in relapsing remitting multiple sclerosis patients, to reveal atrophy rates over the course of 3 years and find a sequence of different central nervous system regions involvement in atrophy.

Methods and materials: 45 relapsing remitting multiple sclerosis patients underwent MRI and neurological examination and were compared to 25 healthy controls. 25 patients were examined in follow-up: during relapse, in 3 months and in 12 months. And 15 patients among them – in 36 months. Neurological deficit was measured w[...]

Results:  Compared to healthy controls, relapsing remitting multiple sclerosis patients experienced GM atrophy of deep regions (p<0.05). Regions of deep gray matter atrophy included thalamus, lentiform and caudate nuclei. Subcortical deep gray matter is highly connected to cortex, and extensive white[...]

Conclusion: The sequence of different regions involvement is detected: subcortical GM, predominantly thalamus, affected first, the next is cortical GM, then WM and the last one is spine. Neurological deficit progression has a correlation with brain and spine atrophy, but does not correlate with T2LV. Disability[...]

Personal information: krotenkova.irina@gmail.com

References: Filippi M. MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines / M. Filippi, M. A. Rocca, O. Ciccarelli, N. De Stefano, N. Evangelou, L. Kappos, A. Rovira, J. Sastre-Garriga, M. Tintorè, J. L. Frederiksen, C. Gasperini, J. Palace, D. S. Reich, B. Banwell, X. Montalban,[...]

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