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C-0702 - Comparison between multiparametric and biparametric MRI protocols for Prostate Cancer detection: a more efficient diagnostic protocol and a viable path toward screening?

L. Basso1, S. Migone2, V. Prono2, M. Baglietto1, F. Rosa1, G. Rescinito1, C. Neumaier1; 1 Genova/IT 2 Genoa/IT Type: Scientific Exhibit
Area of Interests: Oncology, Professional issues, Pelvis
Imaging Techniques: MR-Functional imaging, MR, MR-Diffusion/Perfusion
Procedures: Efficacy studies, Decision analysis, Localisation
Special Focuses: Neoplasia, Tissue characterisation, Image verification
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Aims and objectives: Prostate cancer (PCa) is the most frequent cancer in men in Western World [1]. Despite its low mortality, it has high prevalence with an increased incidence in the last years. This epidemiological trend relies in the more and more diffuse use of PSA, although this biomarker has only moderate accurac[...]

Methods and materials: Patient selection 84 patients suspected to have PCa on the basis of clinical or laboratory data were enrolled in this retrospective study. The median age of the patients was 69,4 (64,2-72,3) and the median serum PSA level was 8,7 ng/ml. Fig. 2 All recruited patients underwent a mp-MRI and a TRUS-bi[...]

Results: Using biparametric MR protocol R1 showed sensitivity of 91%, specificity of 56%, NPV of 53%, PPV of 92% and accuracy of 85%; R2 showed sensitivity of 90%, specificity of 47%, NPV of 53%, PPV of 89% and accuracy of 82%. Using multiparametric MR protocol R1 showed sensitivity of 90%, specificity of 53[...]

Conclusion: Conclusion Our study underlines the feasibility of performing biparametric protocol for PCa detection, without significant lack of diagnostic efficacy compared to mp-MR. Omitting DCE is possible to reduce acquisition time, passing from 45 minutes of multiparametric protocol to 30 minutes of biparame[...]

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References: National Institues of Health. Prostate Cancer. 2012 National Institutes of Health: Bethesda, MD Carter H, Albersten PC, Barry MJ et al. Early detection of prostate cancer: AUA Guideline. J Urol 2013; 190(2): 419-426 Penzkofer T, Tempany-Afdhal CM. Prostate cancer detection and diagnosis: the role of[...]

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