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C-0894 - Quantitative Evaluation of Diffusion – Perfusion Mismatch in Acute Cerebral Infarction Using CT Perfusion

H. YAMAMOTO, M. FUKUNAGA, M. KUMASHIRO; Kurashiki/JP Type: Scientific Exhibit
Area of Interest: Neuroradiology brain
Imaging Technique: CT-Quantitative
Procedures: Thrombolysis, Technology assessment
Special Focuses: Acute, Ischemia / Infarction
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Aims and objectives: Prompt evaluation of cerebral ischemia is important for the treatment of acute cerebral infarction [1-6]. At our hospital, we use both CT perfusion (CBF, CBV, MTT) and MRI diffusion (DWI) to differentiate reversible and non-reversible cerebral ischemia (Fig.1, 2).   Diffusion-perfusion mismatc[...]

Methods and materials: We investigated the data of acute cerebral infarction sixty patients in which occlusion of the internal carotid or middle cerebral artery was detected by CT angiography within twelve hours after onset. Subjects 1. 60 patients (Male 28, Female 32, Age 71.3±9.3) 2. Acute cerebral infarction within 1[...]

Results: There were significant differences between the penumbra and core actual and relative values for CBF, but there was an overlap area (Fig. 9). There were significant differences between the penumbra and core actual and relative values for cerebral blood volume. It is worth noting that the relative cer[...]

Conclusion: The strong correlation between the relative ADC and CBV values suggests that assessment of cerebral edema with relative CBV values might be effective. At the cut-off values of actual 2.0 and 0.95 relative CBV, penumbra and core were clearly differentiated. If CBV is higher than that of the unaffecte[...]

Personal information: Hiroyuki Yamamoto, Department of Radiology, Kurashiki Central Hospital, yhkr@mx1.kct.ne.jp

References: Axel L: Cerebral blood flow determination by rapid-sequence computed tomography theoretical analysis. Radiology, 137, 679-686,(1980). Koenig M, Klotz E, Luka B, et al. Perfusion CT of the brain: Diagnostic approach for early detection of ischemic stroke. Radiology, 209, 85-93,(1998). Thomas E. Ma[...]

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