Local Time : 10:03 CET

B-0367 - Detection and viability of colorectal liver metastases after neoadjuvant chemotherapy: a multiparametric PET/CT-MR study

V. Dunet1, N. Halkic1, A. Anaye2, J. Prior1, C. Sempoux1, A. Denys1, S. Schmidt1; 1 Lausanne/CH 2 Vevey/CH Type: Scientific Paper
Area of Interests: Oncology, Liver
Imaging Techniques: PET-CT, MR, MR-Diffusion/Perfusion
Procedures: Diagnostic procedure, Comparative studies
Special Focuses: Cancer, Metastases, Tissue characterisation
Add poster to my schedule In your schedule (remove)

Purpose: To compare combined gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA)-enhanced and diffusion-weighted (DW) MRI with intravenous (IV) contrast-enhanced 18F-FDG-PET/CT to detect and assess the viability of colorectal liver metastases (CLMs) after neoadjuvant chemotherapy (NAC).[...]

Methods and materials: Between July 2010 and September 2015, 45 patients (age: 63┬▒10y, 29 men [64%]) with colorectal liver metastases (CLMs) were prospectively enrolled after NAC treatment.   All patients underwent Gd-EOB-DTPA-enhanced (EOB Primovist┬«, Bayer, Germany) MRI, DW-MRI and IV contrast-enhanced 18F-FDG-PET/[...]

Results:  Study population   In the 40 operated patients, the combined Gd-EOB-DTPA enhanced and DW-MRI and IV contrast-enhanced 18F-FDG-PET/CT were successfully performed and analyzed. The mean delay between imaging data acquisition and surgical resection was 18 ┬▒ 22 days (range: 2-102 days). Patie[...]

Conclusion: In conclusion, while both combined Gd-EOB-DTPA-enhanced and DW-MRI, and IV contrast-enhanced 18F-FDG-PET/CT allow confident detection of residual CLMs, only 18F-FDG-PET metrics are able to predict TV after NAC. This suggests there is high diagnostic and prognostic potential for hybrid 18F-FDG-PET/MR[...]

Personal information: Dear reader,   I thank you for your interest in our poster. If you wish to obtain more information or to discuss our findings do not hesitate to contact us: sabine.schmidt@chuv.ch  

References: Adam R, de Gramont A, Figueras J, et al. Managing synchronous liver metastases from colorectal cancer: a multidisciplinary international consensus. Cancer Treat Rev. 2015;41:729-741.   Burger IA, Schwarz EI, Samarin A, et al. Correlation between therapy response assessment using FDG PET/CT and [...]

This website uses cookies. Learn more