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C-2552 - Cost-effectiveness of endovascular therapy in acute ischaemic stroke: a metanalysis-based patient subgroup evaluation from a healthcare perspective

W. Kunz1, M. G. M. Hunink2, S. E. Beyer1, F. Meinel1, M. F. Reiser1, W. H. Sommer1, K. Thierfelder1; 1 Munich/DE 2 Rotterdam/NL Type: Scientific Exhibit
Area of Interests: Neuroradiology brain, Management, Interventional vascular
Imaging Techniques: MR-Angiography, Catheter arteriography, CT-Angiography
Procedures: Recanalisation, Decision analysis, Cost-effectiveness
Special Focuses: Economics, Ischemia / Infarction, Embolism / Thrombosis
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Aims and objectives: The currently estimated direct and indirect annual costs of stroke in the United States are 33 billion $1. Improved therapy is an urgent need not only from a medical perspective but also from an economic point of view. Five randomized controlled trials (RCTs) using latest generation endovascular the[...]

Methods and materials: Model Structure   We developed a decision model using decision-analytic software (TreeAge Pro 2016, version 16.1.1.0; TreeAge, Williamstown/MA, USA) to evaluate the cost-effectiveness of EVT+SC versus SC overall and in patient subgroups.   A short-run model was created to analyze costs and[...]

Results: Base-Case Analysis   In the base-case analysis of the total study population using a time horizon of 30 years, EVT+SC led to increased effectiveness of 1.59 QALYs at increased costs of $4,919 compared to SC. The ICER was determined at $3,096/QALY.       Deterministic Sensitivity [...]

Conclusion: The present study investigated the cost-effectiveness of endovascular therapy in different subgroups of acute ischemic stroke patients. In accordance with previous cost-effectiveness analyses7-10, EVT+SC was generally cost-effective compared to SC. While different NIHSS scores and time from symptom [...]

Personal information: Wolfgang G. Kunz, MD Institute for Clinical Radiology, LMU Munich Marchioninistr. 15, 81377 Munich, Germany Phone: +49-(0)89-4400-73250 Fax: +49-(0)89-4400-78832 wolfgang.kunz@med.lmu.de  

References: 1. Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association. Circulation. 2016;133:e38–e360. 2. Goyal M, Demchuk AM, Menon BK, Eesa M, Rempel JL, Thornton J, et al; ESCAPE Trial Investiga[...]

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