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B-0039 - Adjuvant stereotactic body radiotherapy following transarterial chemoembolisation using small diameter drug eluting beads in patients with unresectable hepatocellular carcinoma

A. M. K. Abdel Aal1, K. Mahmoud2, S. Moawad2, S. Kim2, M. M. Hanaoka2, A. Abouarab2, S. Tatum2, R. Jacob2, B. Jackson2, S. Saddekni2; 1 BIRMINGHAM/US 2 Birmingham/US Type: Scientific Paper
Area of Interests: Interventional vascular, Liver
Imaging Technique: Catheter arteriography
Procedures: Stereotactic radiotherapy, Chemoembolisation
Special Focus: Outcomes
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Purpose: The purpose of this study is to assess tumor response and locoregional control in patients with unresectable intermediate-stage hepatocellular carcinoma (HCC) treated with transarterial chemoembolization using small diameter drug-eluting beads (DEB-TACE) compared to DEB-TACE followed by adjuvant ste[...]

Methods and materials: This is a retrospective study including 68 patients diagnosed with HCC. The study included patients with a tumor size ≥ 3 cm treated with either small diameter drug eluting beads 75 µm DEB-TACE (Oncozene Beads, Boston Scientific) alone (n=56) or 75 µm DEB TACE + SBRT of 45 Gy over 3 fractions ([...]

Results: A total of 68 patients were included in this study. A summary of patients demographics are shown in Table 1. There were no significant baseline differences between the two groups apart from the etiology of cirrhosis. The number of lesions was not statistically significant between the 2 group (p=0.77[...]

Conclusion: This retrospective study suggests that in patients with intermediate stage HCC tumors of ≥ 3 cm, treatment with DEB-TACE + SBRT provides a better locoregional disease control and longer PFS compared to DEB-TACE only. However, overall survival is not significantly different between both groups. [...]

Personal information: Ahmed Kamel Abdel Aal, MD, PhD, Division of Interventional Radiology, Department of Radiology, University of Alabama at Birmingham (UAB), Birmingham, AL, USA. E-mail: akamel@uabmc.edu

References: 1. Jacob R, Turley F, Redden DT et al. Adjuvant stereotactic body radiotherapy following transarterial chemoembolization in patients with non-resectable hepatocellular carcinoma tumours of ≥ 3 cm. HPB (Oxford). 2015;17(2):140-9. 2. Marelli L, Stigliano R, Triantos C et al. Treatment outcomes for h[...]

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