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C-2639 - White matter hyperintensities: role of genetic effects in Hungarian twins

A. D. Tarnoki1, B. Forgo2, D. Tarnoki2, D. Kovacs2, L. Kostyal2, C. Oláh2; 1 BUDAPEST/HU 2 Budapest/HU Type: Scientific Exhibit
Area of Interest: Neuroradiology brain
Imaging Technique: MR
Procedure: Screening
Special Focuses: Arteriosclerosis, Epidemiology
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Aims and objectives: Cerebral white matter hyperintensities (WMHs) are commonly observed on MR images of the middle age and rather elderly patients, especially in those with cerebrovascular disease and cardiovascular risk factors (1, 2). Leukoaraiosis is seen as focal or diffuse areas of increased signal intensity. Mild[...]

Methods and materials: 86 healthy volunteering twins (52 monozygotic, MZ and 34 dizygotic, DZ; 61 females, 27 males, age 51±13 years) underwent MR imaging of the brain (Siemens Magnetom Verio 3T) recruited from the Hungarian twin registry (10). Zygosity is assessed with multiple questions and latent class analysis in line[...]

Results: 52 twins (64%) had WMH on FLAIR sequences. Leukoaraiosis was present in 19 subjects (23.5%). Discordance was of the same magnitude in MZ twins compared to DZ twins in case of the presence of leukoaraiosis (2/25, 8% vs. 1/14, 7%) indicating no genetic effect. In case of presence of WMH, DZ discordanc[...]

Conclusion: Our results indicate that number of WMHs have a genetic influence. Leukoaraosis seemed to be determinated by the environment rather than genetic factors. Further studies are needed to confirm our results on a larger twin population using structural equation modeling.

Personal information: Adam Domonkos Tarnoki, MD, PhD, Contact information: Department of Radiology, Semmelweis University, Budapest, Hungary. Address: 78/a Ulloi street, Budapest, H-1082. Phone: +36-30-6401183. Fax: +36-1-2780368. Email: tarnoki2@gmail.com

References: References Carmelli D, DeCarli C, Swan GE, Jack LM, Reed T, Wolf PA, Miller BL. Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins. Stroke. 1998 Jun;29(6):1177-81. Meyer JS, Kawamura J, Terayama Y. White matter lesions in the elderly. J Neurol Sci. 1992[...]

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