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21:58 CET
RC 106 - Merging the best: hybrid imaging
Molecular Imaging Imaging Methods Hybrid Imaging
Wednesday, February 28, 08:30 - 10:00
Room: M 5
Moderator: G. Antoch (Düsseldorf/DE)

A. Hybrid imaging with SPECT/CT
A. F. Scarsbrook; Leeds/GB
Learning Objectives

1. To learn the basic principles of hybrid SPECT/CT imaging.
2. To understand what complementary information can be given by SPECT/CT.
3. To learn about clinical applications of SPECT/CT.


Latest generation SPECT/CT cameras incorporate multi-detector CT and state-of-the-art gamma camera technology in tandem. These scanners improve the efficacy of a wide variety of nuclear medicine tests by providing more accurate localisation of lesions, exclusion of potentially misleading physiological uptake, characterisation of equivocal or indeterminate activity and detection of additional lesions. In addition, they offer the potential for a more efficient "one-stop-shop" imaging approach. Iterative reconstruction algorithms and faster processing power facilitate radiation dose reduction and increased image resolution. The clinical utility of SPECT/CT is diverse and a cross-spectrum of applications in musculoskeletal, oncological, cardiological, endocrine, hepato-biliary and GI tract imaging will be presented.

B. Hybrid imaging with MR/PET
F. M. A. Kiessling; Aachen/DE
Learning Objectives

1. To learn the basic principles of hybrid MR/PET imaging.
2. To understand what new information can be given by MR/PET.
3. To learn about emerging clinical applications of MR/PET.


In this talk an overview on the technological state of the art in PET-MRI as well as an outlook on emerging new technologies will be provided. Concerning the latter in particular new PET-insert solutions will be highlighted that are tailored to specific medical applications and body parts. Besides this, there will be a brief overview on new detector setups providing higher sensitivity and spatial resolution as well as on the methods to improve absorption correction and quantification. In the final part of the talk the focus will be set on the medical applications of PET-MRI. In this context, it will be discussed, which applications inevitably demand for PET-MRI hybrid imaging. Thus, with this talk I will try to convince the audience of the high development potential and clinical value of PET-MRI and its future role in patient management.

C. Hyperpolarised MRI
F. A. Gallagher; Cambridge/GB
Learning Objectives

1. To learn the basic principles of hyperpolarisation.
2. To understand what new information can be given by hyperpolarised MRI.
3. To learn about oncological and non-oncological applications of hyperpolarised MRI.


There is increasing evidence to support a role for metabolism in many diseases; for example, deregulation of cellular energetics is now considered to be one of the key hallmarks of cancer. There are a number of imaging methods that have been used to probe this metabolism: the most widely available is 18F-fluorodeoxyglucose (FDG), an analogue of glucose, used in PET. Hyperpolarised carbon-13 MRI (13C-MRI) is an emerging molecular imaging technique for studying cellular metabolism, particularly in the fields of oncology and cardiology. This method allows non-invasive measurements of tissue metabolism in real-time. To date, the most promising probe used in conjunction with hyperpolarised MRI has been 13C-labelled pyruvate: pyruvate is metabolised into lactate in normal tissue in the absence of oxygen, but in tumours this occurs very rapidly even in the presence of oxygen. Results from many animal models have shown that there is a reduction in the metabolism of pyruvate to lactate following successful treatment with chemotherapy. In the heart, pyruvate is also metabolised to carbon dioxide in addition to lactate and this balance between anaerobic and aerobic metabolism alters in many disease states. There are now a small number of sites performing human hyperpolarised carbon-13 MRI imaging. This talk will discuss the progress that has been made in this field within the areas of oncology and cardiology and potential clinical applications.

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