Does hypertension affect the aging of white matter? - insights from DTI.
Aims and objectives:
In the hypertensive patients’ population WM microstructure differences derived from DTI studies were reported in the corpus callosum. [Gons 2012, Maillard 2012] Additionally the SBP was linearly correlated with decreased regional FA and increased MD, especially in anterior corpus callosum, the infer[...]
Methods and materials:
One hundred forty six participants took part in the study : the control group (CON) of 61 healthy individuals and the subjects group (SUB) of 85 hypertensive patients. Age categories were as follows: - group I - aged to 47 (CON N=22, SUB N=24) ; - group II - aged from 48 to 56 years (CON N=19, SUB N[...]
The two-way ANOVA of diffusion coefficients of the nerve pathways, showed an age-related main effect in most of the cases (Fig. 2). In contrast, tracts such as: left and right anterior thalamic radiation (in MD, RD, AD) (Fig. 3), corticospinal tract R (in MD, AD), left cingulum cingulate gyrus (in M[...]
On the basis of our results, a model of brain aging different between the hemispheres emerges. Healthy and hypertensive individuals have different aging patterns. Hypertension and age independently affected diffusion parameters in projection pathways, whereas in association fibers an additional spat[...]
Gons, R. A. R., van Oudheusden, L. J. B., de Laat, K. F., van Norden, A. G. W., van Uden, I. W. M., Norris, D. G., … de Leeuw, F.-E. (2012). Hypertension is Related to the Microstructure of the Corpus Callosum: The RUN DMC Study. Journal of Alzheimer’s Disease, 32(3), 623–631. https://doi.org/10.323[...]