1. To describe the behavior of human papilloma virus.
2. To understand the specific biology and imaging features of HPV - positive cancer of the head and neck.
3. To become familiar with effective diagnostic imaging procedures, treatment and follow-up of these tumour.
Head and neck cancer is a commonly encountered pathology. Oropharyngeal location of the disease is increasing rapidly, affecting young people and its relation with oropharyngeal infection by oncogenic type-16 human papillomavirus (HPV) has been proven. The clinical and biologic profile of HPV-positive patients is distinct from any other head and neck squamous cell cancer patients, however, it is not possible to differentiate the HPV status based on imaging studies. HPV-positive patients have a tendency towards early lymph nodes metastasis, more frequent distant metastatic disease and much better response to non-surgical treatment, comparing to HPV-negative ones. Detection of intratumoral oncogenic HPV DNA seems to be mandatory now, since it determines prognosis in terms of long-term survival and locoregional control. A policy of vaccination for both girls and boys may be the key answer to a growing number of this particular cancer