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C-1469 - Effect of Oxygen Inhalation in Pharmacokinetic Analysis: a Preliminary Study
N. Arai1, H. Kan1, H. Kasai1, S. Tsubokura1, K. Mizuno1, M. Takizawa2, K. Omori2, Y. Hirose1, Y. Shibamoto1; 1Nagoya/JP 2Kashiwa/JP
Type: Scientific Exhibit
Area of Interest: MR physics
Imaging Technique: MR
Procedure: Contrast agent-other
Special Focus: Blood

Aims and objectives:
Pharmacokinetic (PK) analysis has been used to quantify the number of microvessels in each region, and it reflects microvascular flow and volume transfer constant [1-7]. Meanwhile, the oxygen leads to relatively T1 changes [8-10] compared with natural variation in protein or macromolecular concentra[...]
Methods and materials:
Blood T1 was measured dynamically in volunteers as the inhaled gas was switched from room air to 100% oxygen and back to room air ( Fig. 2 ). In the beginning, the T1 of arterial blood was measured in room air, which was pre-oxygenated. Then, 100% oxygen was inhaled at a rate of 10 L/min during the [...]
Results:
The dissolved molecular oxygen in arterial blood demonstrated a significantly larger the R1 (shorter the T1) than pre-oxygenated blood. It was immediately noted after 100% oxygen was inhaled within 2.5 min ( Fig. 4 and Fig. 5 ). Following that, no significant differences were observed in the R1 of a[...]
Conclusion:
Oxygen inhalation shortens the T1 of arterial blood and has a potential to work at once, which affects PK analysis that uses the T1 of pre-contrast scans and leads to a change in C(t). Beyond that, it has a considerable influence on the volume transfer constant Ktrans.
Personal information:
Nobuyuki Arai, MS, Department of Radiology, Nagoya City University Hospital. 1-Kawasumi, Mizuho-cho Mizuho-ku, Nagoya City, Aichi, 467-8602, Japan. E-mail address: rarai51@med.nagoya-cu.ac.jp Hirohito Kan, PhD, Department of Radiology, Nagoya City University Hospital. Harumasa Kasai, PhD, D[...]
References:
1. Barrett T, Brechbiel M, Bernardo M, et al. MRI of tumor angiogenesis. J Magn Reson Imaging. 2007; 26(2): 235-249. 2. Matsumoto S, Yasui H, Batra S, et al. Simultaneous imaging of tumor oxygenation and microvascular permeability using Overhauser enhanced MRI. Proc Natl Acad Sci U S A. 2009; 106(4[...]

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