Aims and objectives:
Radiofrequency ablation (RFA) is a minimal-invasive treatment option for liver malignancies, e.g. hepatocellular carcinoma or metastases. With the help of computed tomography or ultrasound, an electrode is inserted into the hepatic malignancy. A current flow is applied to it, causing thermal heating[...]
Methods and materials:
Fresh bovine livers were obtained from a local distributor. We used a standard commercially available RF generator (StarBurst© RITA© 1500X, AngioDynamics, Inc., Queensbury, NY, U.S.A.) with IntelliFlow peristaltic infusion pump in combination with a 17-gauge monopolar perfusion RF electrode (StarBur[...]
Volume calculation based on three-axis measurements from DECT showed ablation defects sized 7,6 ± 1,5 cm3 (5 min; n = 5), 18,5 ± 3,4 cm3 (10 min; n = 5), and 45,9 ± 4,1 cm3 (15 min; n = 5) when using isotonic saline (NaCl 0,9 %; Fig. 1), respectively. The mean volumes were increased to 18,9 ± 2,6 cm[...]
Thus, continuous hypertonic saline infusion may be an efficient and easy-to-use modification of standard RFA procedure in order to achieve markedly increased ablation defects. Consequently, we intend transferring the modified RFA procedure using continuous NaCl 20% infusion to further live animal an[...]
Livraghi T, Goldberg SN, Monti F, Bizzini A, Lazzaroni S, Meloni F, et al. Saline-enhanced radio-frequency tissue ablation in the treatment of liver metastases. Radiology. 1997 Jan;202(1):205–10.